In the United States, cocaine abuse remains a big public health issue. Even though many patients who rely on cocaine respond successfully to addiction therapy, conventional psycho-social care is not appropriate for many.

The development of an appropriate drug to combat dependency is also a research priority. Advances in studying cocaine abuse neurobiology have culminated in the discovery of some good therapies that have now produced promising effects in controlled clinical trials.

The existence of symptoms of cocaine withdrawal can make a period of initial abstinence difficult for cocaine users. The effects of cocaine withdrawal include dysphoric mod, and tiredness. In some trials, patients who undergo medication with extreme cocaine withdrawal signs have found to be more likely than other patients to leave prematurely and are less able to maintain cocaine abstention in outpatient.

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  • Propranolol- Propranolol, the beta-blocker, seems to be promising for the treatment of patients who have extreme withdrawal effects with cocaine. Beta blocker is used mainly to treat angina and high blood pressure, but it is also used to control anxiety and restlessness.
  • GABA B agonist used for muscle relaxing is baclofen. As a GABA agonist, baclofen can reduce the amount of dopamine emanated from cocaine stimulus or cocaine crave into the nucleus.
  • Tiagabine is another GABAergic drug that could promise cocaine dependency therapy. Tiagabine is a GABA reuptake transmitter style selective blocker and is currently approved for seizure control.
  • Topiramate can be a fine complementary preventive drug dependent on its effects on both GABA and glutamate neurotransmission. Topiramate raises GABA’s cortical levels and allows GABA neurotransmission simpler
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